Division of Cardiology, Geneva University Hospitals, Geneva, Switzerland. Department of Cardiology, Lausanne University Hospital, Lausanne, Switzerland. Clinical Trials Unit Bern, University of Bern, Bern, Switzerland. Department of Cardiology, Triemli Hospital, Zurich, Switzerland. Department of Cardiology, Kantonsspital, Aarau, Switzerland. Department of Cardiology, Kantonsspital, St Gallen, Switzerland. Department of Cardiology, Basel University Hospital, Basel, Switzerland. Department of Cardiology, Hôpital du Valais, Sion, Switzerland. Department of Cardiology, Inselspital, Bern University Hospital, Bern, Switzerland. Applied Health Research Centre, Li Ka Shing Knowledge Institute of St Michael's Hospital, Department of Medicine and Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada. Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland. Department of Cardiology, Inselspital, Bern University Hospital, Bern, Switzerland. Electronic address: stephan.windecker@insel.ch.